Metallionenivåer i blod fra pasienter med metall-mot-metall-hofteprotese

BACKGROUND A BHR (Birmingham hip resurfacing) prosthesis was implanted in 445 people Norway. Adverse reactions can arise as a result of the release metal ions from metal-on-metal joint surfaces made cobalt-chromium alloy. The aim study to analyse during first five years after surgery patients with and investigate whether this linked clinical complications. MATERIAL AND METHOD Forty-four male (median age 53 years) at Coastal Hospital Hagevik period October 2009 May 2013 were monitored by means blood samples before implantation three months, one year, afterwards. Analyses cobalt chromium whole performed. Function scoring used clinically assess prosthetic joint. RESULTS Metal ion concentrations increased between date year later (p < 0.001), subsequently remained stable. After years, median (min.- max.) 1.1 µg/L (0.4-6.3 µg/L) 1.4 (0.4-11.7 respectively for unilateral prostheses (n = 36), 2.3 (1.6-28.5 2.6 (1.7-14.1 bilateral 8). Five underwent revision surgery, while other had good function. INTERPRETATION Patients significant increase their but levels still well below threshold value 7 ?g/L, which indicates an risk